Bio-Shift is a unique enzyme formulation especially designed to break down biofilm embedding potential gastrointestinal pathogens. Enzymes in Bio-shift are selected for their ability to lyse the extracellular polymers commonly found in biofilm as well as degrade bacterial and yeast cell wall structures. The lytic effect of Bio-shift on biofilm has been documented using the well-established MBEC™ P&G assay for antibiofilm activity. Bio-shift is intended for use in conjunction with efforts to support normal gastrointestinal function and microbiota. Bio-shift is recommended as an adjunct to other efforts to eliminate potential pathogens. These efforts are best combined with use of a high-potency, broad, multispecies probiotic formulation and a prebiotic to encourage the formation of healthy intestinal microbial biofilm communities. Bio-shift may also be combined with antimicrobial agents.