Saw palmetto, pygeum and beta–sitosterol offer support for healthy urinary function, in part by maintaining healthy hormone metabolism and enzyme activities. A meta–analysis involving 18 randomized controlled trials and almost 3,000 men indicated that saw palmetto provided positive support for urinary health. In a related meta–analysis, pygeum demonstrated similar support. A randomized, double blind, placebo–controlled, multicenter study with 200 male subjects revealed that beta–sitosterol also provides promising urinary function support. These actions are combined with the powerful prostate cell support potential of antioxidants, vitamins, minerals and herbs included in this formula. Data from over 47,000 participants in the Health Professionals Follow–Up Study suggested that tomato or lycopene intake was positively associated with prostate cell health. Healthy plasma concentrations of alpha–tocopherol, selenium and zinc have also been associated with maintaining healthy prostate cell metabolism. In one large cohort study involving 29,133 men, alpha–tocopherol supplementation provided healthy cell support for the prostate. Vitamin D, curcumin and green tea play key roles in prostate cell health, including support for healthy matrix metalloproteinase (MMP) activity, cell receptor function and cell signaling. Pomegranate and silymarin provide enhanced antioxidant support and promote healthy prostate cell cycle function.